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Pharmaceuticals

Pharmaceuticals

Elemental / phase analysis to molecular structure

In medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are discovered and designed. In the recent past, most drugs have been discovered either by identifying the active ingredient from traditional remedies or by serendipitous discovery. A new approach, using so-called "rational drug design", has been to understand how disease and infection are controlled at the molecular and physiological level and to target specific entities based on this knowledge. Given this importance, Rigaku has been at the forefront in the development of single crystal diffraction for both macromolecular and small molecule structure determination. Rigaku products range from crystal diffraction screening and high-resolution data collection systems to 3D structure refinement and imaging software.

X-ray powder diffraction is extensively used in the drug discovery, design, development and formulation processes to obtain critical knowledge about pharmaceutical products. Many parameters required by the FDA, legal patent issues and drug performance are only accessible by employing XRD. With the introduction of systems specifically developed with the pharmaceutical industry in mind, XRD is now both cost-effective and easy-to-use. Phase analysis and polymorph identification are common analytical needs within both pharmaceutical development and production. In addition, crystal structure determination, the study of non-ambient behavior, and overall morphology help to provide a complete understanding of the properties of a pharmaceutical agent.

Handheld Material Analysis

The Rigaku Progeny 1064 nm handheld Raman analyzer transforms material analysis for pharmaceutical companies by integrating the most versatile tool into existing workflows. Progeny utilizes 1064 nm-based Raman spectroscopy enabling accurate analysis through packaging for raw material identification (RMID), verification of finished products, or authentication for anti-counterfeit prevention.
 

Rigaku recommends the following systems:


WDXRF

Benchtop tube below sequential WDXRF spectrometer analyzes O through U in solids, liquids and powders

High power, tube below, sequential WDXRF spectrometer with Smart Sample Loading System (SSLS)

High power, tube above, sequential WDXRF spectrometer with new ZSX Guidance expert system software

High power, tube above, sequential WDXRF spectrometer

WDXRF spectrometer designed to handle very large and/or heavy samples

High-throughput tube-above multi-channel simultaneous WDXRF spectrometer analyzes Be through U

Tube below, single element WDXRF analyzer for quality control applications

High-power, tube-below, sequential WDXRF spectrometer with new ZSX Guidance expert system software

Single crystal

Our most popular diffractometer for single crystal analysis, configured with either single or dual microfocus sealed tube X-ray sources and an extremely low noise direct X-ray detection detector.

A benchtop single crystal X-ray diffractometer ideal for chemical crystallography and teaching.

A modern single crystal X-ray diffractometer for structural analysis configured with microfocus sealed tube technology and a direct X-ray detection detector.

Our most popular diffractometer for measuring difficult samples, configured with a high-flux rotating anode X-ray source and an extremely low noise direct X-ray detection detector.

A dual-wavelength, high-flux, rotating anode X-ray diffractometer specifically configured for measuring difficult samples as well as providing versatility through multiple wavelengths.

A bespoke, extremely high-flux diffractometer with custom enclosure and the flexibility to utilize both ports of the rotating anode X-ray source.

A curved single crystal X-ray diffraction detector based on direct X-ray detection technology with a higher 2θ range compared to a flat detector.

XRD

New 6th-generation general purpose benchtop XRD system for phase i.d and phase quantification

Advanced state-of-the-art high-resolution XRD system powered by Guidance expert system software

Highly versatile multipurpose X-ray diffractometer with built-in intelligent guidance

High-performance, multi-purpose XRD system for applications ranging from R&D to quality control

Raman

Handheld Raman for raw material identification and finished product authentication using 1064 nm Raman analysis.

Small Molecule

User-inspired data collection and data processing software for small molecule and protein crystallography.

The smallest detachable motorized goniometer head on the market.

Robotic sample changer to provide unattended data acquisition, enhanced productivity and standardized workflow to your research environment.

Protein

Automated tool for performing in situ crystallography experiments on existing X-ray diffractometers.

Automated crystal transport, orientation and retrieval robot specifically designed for high throughput structural biology.

A customized single crystal X-ray diffraction system that has the capabilities of utilizing both ports of a rotating anode X-ray source.

EDXRF

Performance EDXRF elemental analyzer measures Na to U in solids, liquids, powders and thin-films

New variable collimator small spot 60 kV EDXRF system featuring QuantEZ software.

EDXRF spectrometer with powerful Windows® software and optional FP.

High-performance, Cartesian-geometry EDXRF elemental analyzer measures Na to U in solids, liquids, powders and thin films

Detectors

PILATUS3 R hybrid pixel array detector (HPAD) for X-ray crystallography

2D X-ray detector with latest semiconductor technology designed for home lab diffractometers

Extremely low noise, compact, detector based on direct X-ray detection technology.

A curved detector based on direct X-ray detection technology with the highest 2θ range at a single position available for the home lab.

SAXS

Small angle X-ray scattering (SAXS) Kratky camera system.

X-ray CT

High-speed, stationary sample microtomography of large samples

Ultra-high resolution nanotomography using parallel beam geometry

High-resolution benchtop microtomography of large samples

Thermal Analysis

TG-DTA is a hyphenated technology generally referred to as simultaneous thermal analysis (STA).

 

 

Applications

The following applications are relevant to this industry

Raman

Small Molecule, Single crystal

Protein, Single crystal

XRD

X-ray Imaging

Thermal Analysis

XRD, Thermal Analysis

WDXRF

Total reflection XRF (TXRF)

EGA, Thermal Analysis

SAXS, Protein, Single crystal

Small Molecule

Protein

Protein, Single crystal, Optics