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Pharmaceuticals

Pharmaceuticals

Elemental / phase analysis to molecular structure

X-ray diffraction (XRD) and X-ray fluorescence (XRF) are established analytical methods in drug discovery and production quality control. From identification of active ingredient (API) via traditional remedies or by serendipitous discovery to so-called "rational drug design," Rigaku has been on the forefront in the development of single crystal diffraction instruments and software for both macromolecular and small molecule structure determination. Many aspects of discovery, design, development and formulation processes require structural information acquired by X-ray diffraction techniques. Phase analysis and polymorph identification are common analytical needs within both pharmaceutical development and production. Rigaku offers a range of instruments and software solutions to ensure critical quality attributes (CQAs) and process parameters (CPPs) for regulated (FDA part11 compliant) and non-regulated environments. Rigaku products range from crystal diffraction screening and high-resolution data collection systems to 3D structure refinement and imaging software.

Handheld Material Analysis

The Rigaku Progeny 1064 nm handheld Raman analyzer transforms material analysis for pharmaceutical companies by integrating the most versatile tool into existing workflows. Progeny utilizes 1064 nm-based Raman spectroscopy enabling accurate analysis through packaging for raw material identification (RMID), verification of finished products, or authentication for anti-counterfeit prevention.
 

Rigaku recommends the following systems:


WDXRF

Benchtop tube below sequential WDXRF spectrometer analyzes O through U in solids, liquids and powders

High power, tube below, sequential WDXRF spectrometer with Smart Sample Loading System (SSLS)

High power, tube above, sequential WDXRF spectrometer with new ZSX Guidance expert system software

High power, tube above, sequential WDXRF spectrometer

WDXRF spectrometer designed to handle very large and/or heavy samples

High-throughput tube-above multi-channel simultaneous WDXRF spectrometer analyzes Be through U

Tube below, single element WDXRF analyzer for quality control applications

High-power, tube-below, sequential WDXRF spectrometer with new ZSX Guidance expert system software

Single crystal

Our most popular diffractometer for Chemical Crystallography and Mineralogy, configured with either single or dual microfocus sealed tube X-ray sources and an extremely low noise direct X-ray detection detector.

A benchtop single crystal X-ray diffractometer ideal for chemical crystallography and teaching.

An entry-level single crystal X-ray diffractometer for Chemical Crystallography configured with microfocus sealed tube technology and a direct X-ray detection detector.

Our most popular diffractometer for Protein Crystallography, configured with a high-flux rotating anode X-ray source and an extremely low noise direct X-ray detection detector.

Spectacular performance combined with dual wavelength versatility, provides the perfect answer for high-capacity Chemical Crystallography labs or for X-ray facilities that support Chemical Crystallography and Protein Crystallography.

A bespoke, extremely high-flux diffractometer with custom enclosure and the flexibility to utilize both ports of the rotating anode X-ray source.

A curved single crystal X-ray diffraction detector based on direct X-ray detection technology with a higher 2θ range compared to a flat detector.

XRD

New 6th-generation general purpose benchtop XRD system for phase i.d and phase quantification

Advanced state-of-the-art high-resolution XRD system powered by Guidance expert system software

Highly versatile multipurpose X-ray diffractometer with built-in intelligent guidance

High-performance, multi-purpose XRD system for applications ranging from R&D to quality control

Raman

Handheld Raman for raw material identification and finished product authentication using 1064 nm Raman analysis.

Small Molecule

User-inspired data collection and data processing software for small molecule and protein crystallography.

The smallest detachable motorized goniometer head on the market.

Robotic sample changer to provide unattended data acquisition, enhanced productivity and standardized workflow to your research environment.

Protein

Automated tool for performing in situ crystallography experiments on existing X-ray diffractometers.

Automated crystal transport, orientation and retrieval robot specifically designed for high throughput structural biology.

EDXRF

Performance EDXRF elemental analyzer measures Na to U in solids, liquids, powders and thin-films

New variable collimator small spot 60 kV EDXRF system featuring QuantEZ software.

EDXRF spectrometer with powerful Windows® software and optional FP.

High-performance, Cartesian-geometry EDXRF elemental analyzer measures Na to U in solids, liquids, powders and thin films

Detectors

PILATUS3 R hybrid pixel array detector (HPAD) for X-ray crystallography

2D X-ray detector with latest semiconductor technology designed for home lab diffractometers

Extremely low noise, compact, detector based on direct X-ray detection technology.

A curved detector based on direct X-ray detection technology with the highest 2θ range at a single position available for the home lab.

SAXS

Small angle X-ray scattering (SAXS) Kratky camera system.

X-ray CT

High-speed, stationary sample microtomography of large samples

Ultra-high resolution nanotomography using parallel beam geometry

High-resolution benchtop microtomography of large samples

Thermal Analysis

TG-DTA is a hyphenated technology generally referred to as simultaneous thermal analysis (STA).

 

 

Applications

The following applications are relevant to this industry

Raman

Small Molecule, Single crystal

Protein, Single crystal

XRD

X-ray Imaging

Thermal Analysis

WDXRF

Total reflection XRF (TXRF)

EGA, Thermal Analysis

SAXS, Protein, Single crystal

Small Molecule

Protein

XRD, Thermal Analysis

Protein, Single crystal, Optics