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Thermal behavior analysis of over-the-counter (OTC) drugs

TA-6006: Thermal behavior analysis of over-the-counter (OTC) drugs


The detection or analysis of the gases evolved during a chemical reaction, as a function of temperature, constitute the techniques of thermal analysis called evolved gas detection (EGD) and evolved gas analysis (EGA), respectively.

Thermal analysis using mass spectrometry covers a large number of related and analytical powerful techniques such as evolved gas analysis using mass spectrometry (EGA-MA) including termogavimetry-mass spectrometry (TG-MS), temperature programmed pyrolysis-mass spectrometry and temperature programmed desorption mass spectrometry.

In conventional EGA-MS, the evolved gaseous products, which are introduced rapidly to MS, are generally ionized by electron ionization (EI) at 70eV. In this case, a part of the evolved gaseous molecular ion undergoes further decomposition, and observed simultaneously ions. Especially in the thermal processes, since the evolved gases consists of multiple gaseous species in almost all cases, the resulting fragment ions are overlapped, while the fragment ions provide significant information concerning the structure of the molecule, the apparent mass spectra can be quite complicated. In order to differentiate in real-time the multiple organic species that are evolved in the thermal process, one feasible approach is the use of MS with a selective and soft (fragment-free) ionization technique which avoids fragmentation during ionization.

We evaluate the thermal behavior of the over-the-counter product employed the combination of thermograbimetry (TG), differential thermal analysis (DTA) and photo ionization mass spectrometer (PI-MS). The photo ionization mass spectrometer is available to detect and discriminate in real time the molecular state of decomposition gas which corresponded to mass change by heating, it is useful to analyze the thermal cracking process of drug and, it improves the analytical precision and measurement efficiency.

Evolved gas analysis products from Rigaku

In TG-FTIR, gases evolved by volatilization or thermal decomposition are qualitatively analyzed, which allows you to track changes in the generated amount along with the temperature change.