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Protein / macromolecular crystallography

Protein crystallography

3D structure of large biological molecules

This technique employs single crystal X-ray diffraction (SXRD) to unambiguously determine the three-dimensional structure of large biological molecules. The determination of such molecules gives researchers insight into biology and life at the molecular level.  Given the importance of this research, Rigaku has been at the forefront in the development of a wide range of instrumentation related to various aspects of macromolecular crystallography.

One important application is structure-based drug design, a technique by which drugs are designed based on a knowledge of the three-dimensional structure of an enzyme’s active site.

Rigaku recommends the following products:

A customized single crystal X-ray diffraction system that has the capabilities of utilizing both ports of a rotating anode X-ray source.

A microfocus sealed tube single crystal X-ray diffractometer that is low maintenance and perfect for screening and evaluating protein crystals.

A single crystal X-ray diffractometer with high-flux microfocus rotating anode X-ray generator and direct detection, HPC X-ray detector.

A versatile and high-flux dual-wavelength (DW) X-ray diffractometer with an HPC X-ray detector for multipurpose diffraction experiments

Single wavelength Confocal Max-Flux (CMF) optics for single crystal diffraction

Automated tool for performing in situ crystallography experiments on existing X-ray diffractometers

Small angle X-ray scattering (SAXS) Kratky camera system

User-inspired data collection and data processing software for small molecule and protein crystallography

A unique curved single crystal X-ray diffraction detector based on direct X-ray detection technology with the highest 2θ range at a single position available for the home lab.

Extremely low noise, air-cooled X-ray detector based on direct X-ray detection technology.

High-resolution X-ray detectors for X-ray diffractometers from DECTRIS

Automated crystal transport, orientation and retrieval robot

The smallest detachable motorized goniometer head on the market

Applications

The following applications are relevant to this technique

Protein

Small Molecule