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Protein / macromolecular crystallography

Protein crystallography

3D structure of large biological molecules

This technique employs single crystal X-ray diffraction (SXRD) to unambiguously determine the three-dimensional structure of large biological molecules. The determination of such molecules gives researchers insight into biology and life at the molecular level.  Given the importance of this research, Rigaku has been at the forefront in the development of a wide range of instrumentation related to various aspects of macromolecular crystallography.

One important application is structure-based drug design, a technique by which drugs are designed based on a knowledge of the three-dimensional structure of an enzyme’s active site.

Rigaku recommends the following products:

A customized single crystal X-ray diffraction system that has the capabilities of utilizing both ports of a rotating anode X-ray source.

Single wavelength Confocal Max-Flux (CMF) optics for single crystal diffraction

Our most popular diffractometer for single crystal analysis, configured with either single or dual microfocus sealed tube X-ray sources and an extremely low noise direct X-ray detection detector.

Our most popular diffractometer for measuring difficult samples, configured with a high-flux rotating anode X-ray source and an extremely low noise direct X-ray detection detector.

A dual-wavelength, high-flux, rotating anode X-ray diffractometer specifically configured for measuring difficult samples as well as providing versatility through multiple wavelengths.

A bespoke, extremely high-flux diffractometer with custom enclosure and the flexibility to utilize both ports of the rotating anode X-ray source.

Robotic sample changer to provide unattended data acquisition, enhanced productivity and standardized workflow to your research environment.

Automated tool for performing in situ crystallography experiments on existing X-ray diffractometers.

User-inspired data collection and data processing software for small molecule and protein crystallography.

Automated crystal transport, orientation and retrieval robot specifically designed for high throughput structural biology.

A curved detector based on direct X-ray detection technology with the highest 2θ range at a single position available for the home lab.

A curved single crystal X-ray diffraction detector based on direct X-ray detection technology with a higher 2θ range compared to a flat detector.

Extremely low noise detector based on direct X-ray detection technology.

Small angle X-ray scattering (SAXS) Kratky camera system.

High-resolution X-ray detectors for X-ray diffractometers from DECTRIS.