Crystals containing long unit cell axes are often challenging samples requiring extended data collection strategies in order to collect good publishable quality data. This is mainly due to the overlap of reflections, which complicates data processing and therefore requires longer crystal-to-detector distances to minimize overlap. Long unit cell axes often arise when the contents of the cell are large; e.g. proteins, macrocyclic host-guest complexes, or when the Z’ number for a small molecule is high. Overlapping of reflections can also occur in non-merohedrally twinned samples where the multiple components have intersecting lattices. Here we show the advantages of using a Hybrid Photon Counting (HPC) detector to overcome the challenges of overlapping reflections.