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Quantitative analysis of crystal polymorphs by the DD method

AppNote B-XRD1142: Quantitative analysis of crystal polymorphs by the DD method


In the Direct Derivation (DD) method, quantitative analysis is performed using the sum of the X-ray intensities scattered from each crystalline phase and the chemical composition information. In some fields, such as pharmaceuticals, many compounds are not listed in databases. In these cases, it is difficult to calculate quantitative values using conventional methods, and thus quantitative analysis using the DD method is considered effective. In this example, each crystalline phase of a compound having different polymorphic forms was measured, and then quantitative analysis of a mixture using the results from the pure forms was performed.

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