Pharmaceutical Excipients Identification with Handheld Raman

Application Note RAD006


RAD006 stickerIt is critical and required for pharmaceutical manufacturers to have quality control procedures in place to ensure incoming raw materials are both correct and meet sufficient quality standards. Many have adopted Raman spectroscopy as an effective and efficient technique for raw material identification, in-process analysis, and final product authentication.

Minimize sample interference while maximizing efficiency

While analyzing excipients, fluorescence interference frequently prevents successful chemical identification and/or analysis. The Rigaku Progeny utilizes a 1064 nm laser to minimize signal-blocking fluorescence. To demonstrate the advantages, four common excipients used in many pharmaceutical products were analyzed using 1064 nm and 785 nm Progeny 1064 nm Advanced Analysis Technology analyzers (Figures 1-4). 

RAD006 Figure 1 Sodium carboxymethyl celluloseFigure 1: Sodium carboxymethyl cellulose 785 nm and 1064 nm 

RAD006 Figure 2 Alginic acid sodium salt

Figure 2: Alginic acid sodium salt 785 nm and 1064 nm

RAD006 Figure 3 Gelatin

Figure 3: Gelatin 785 nm and 1064 nm 

RAD006 Figure 4 Hydroxyproyl methyl cellulose

Figure 4: Hydroxyproyl methyl cellulose 785 nm and 1064 nm 


Because of its ability to test the full range of materials covered by a 785 nm system and the added ability to cover materials blocked by fluorescence, the Progeny 1064 nm analyzer offers the most comprehensive material identification range in a handheld form. Manufacturers can now perform lab-quality analysis at any point in their production process, enabling stronger quality programs.

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1428268_ExcipientsApplicationNote_080522 (1)


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