TOPIQ | XtaLAB Synergy-ED: Single Crystal Structures from Powders

Presenter: Dr. Joseph Ferrara

The Rigaku XtaLAB Synergy-ED is a fully integrated electron diffractometer, with a seamless workflow from data collection to 3D structure determination. The XtaLAB Synergy-ED is the result of Rigaku’s collaboration with JEOL, synergistically combining each partner’s core technologies: Rigaku’s hybrid pixel array detector (HyPix-ED) and CrysAlis^Pro software, and JEOL’s long-standing excellence in electron beam generation and control. Using MicroED, a three-dimensional electron diffraction method, single crystals of all classes below one micron in size can be studied. The XtaLAB Synergy-ED offers the ability to determine the single crystal structure from a single grain from powder samples. In fact, one can determine the single crystal structure of multiple compounds present in a single powder sample.

There are two well-characterized polymorphs of acetaminophen with known single crystal structures. In this presentation we will explore the case of a third polymorph of acetaminophen generated in an XRD-DSC experiment with a structure determined by MicroED. This result is a major step in understanding the properties of acetaminophen and demonstrates the potential to solve many more unsolved problems in structural science.