XtaLAB Synergy Flow

Intelligent Workflow Automation

Unattended data acquisition, enhanced productivity and standardized workflow

The XtaLAB Synergy product line has proven to be very popular for single crystal analysis. With the choice of a range of high-performance X-ray sources as well as direct X-ray detection detectors, there is a model of the XtaLAB Synergy to meet the needs of any researcher. The XtaLAB Synergy Flow system allows you to now take full advantage of the performance of your system by incorporating a 6-axis UR3 Universal Robot which provides unattended data acquisition, enhanced productivity and standardized workflow for your research environment. The XtaLAB Synergy Flow can be configured with the XtaLAB Synergy-S, XtaLAB Synergy-R, and XtaLAB Synergy-DW VHF models. 

XtaLAB Synergy Flow Overview

A XtaLAB Synergy Flow system can be used as part of a sample submission protocol that minimizes human contact. With automated sample mounting, potential contamination of the diffractometer by human contact is eliminated. A crystal capacity of 48 samples means that unattended data collection can be easily performed, thus minimizing the time required to be in the X-ray laboratory. 

A negative aspect of existing automated diffractometers is that data collection must be halted in order to open the enclosure and add more samples. The XtaLAB Synergy Flow system avoids that problem by incorporating a unique X-ray safe dewar-drawer system which can be ejected from the side of the cabinet while data collection continues unimpeded.

The XtaLAB Synergy Flow is controlled by CrysAlisPro for frustration-free operation including sample addition, experiment queuing and sample sorting. Samples can be sorted into "good" pucks, which can then be queued up for long experiments or removed and stored for transport to a synchrotron. Judgements on good samples can be made automatically or by the user on inspection of the results later.

The XtaLAB Synergy Flow system utilizes the Intelligent Goniometer Head (IGH), a motorized marvel with fast response and intelligence built in. Automated sample centering can be as fast as 6 seconds on dual-camera systems, the standard for our robotic instruments. Manual and point and click control are also available for fine-tuning centering or targeting a specific feature or part of the sample.

Samples are stored in an LN2 dewar, with a capacity of 48 samples stored in three uni-pucks. Dewar accessories include a bar code reader, a defrost system, rotatable lid, level sensor and automatic LN2 dosing system. Accepted pins include the ALS standard from ALS and the SPINE standard from EMBL.

The XtaLAB Synergy diffractometers are known for high-performance X-ray sources and direct X-ray detection detectors, a combination that means amazing throughput potential. The XtaLAB Synergy Flow system was designed to take full advantage of the high performance by minimizing the time that an instrument might sit idle due to lack of human interaction. In the current climate of minimizing human interaction and maximizing efficiency and productivity, the XtaLAB Synergy Flow provides a transformational instrument for today’s single crystal X-ray laboratories.

XtaLAB Synergy Flow Features

Unattended data acquisition, enhanced productivity and standardized workflow
Take full advantage of the speed and performance of your Synergy diffractometer by eliminating wasted time between samples
Automated method of pre-screening protein samples before shipping to the synchrotron
Reliable automated sample centering using optical object centering; centering in as little as 6 seconds

XtaLAB Synergy Flow Specifications

Attributes X-ray diffractometer with robotic sample changer
Diffractometer models XtaLAB Synergy-S, XtaLAB Synergy-R and XtaLAB Synergy-DW VHF
Robot UR3 6-axis universal robot; positioning accuracy ±0.01 mm
Goniometer head Intelligent Goniometer Head (IGH)
Dewar capacity 48 samples can be stored in three uni-pucks
Pin formats ALS standard and the SPINE standard from EMBL

XtaLAB Synergy Flow Application Notes

The following application notes are relevant to this product

XtaLAB Synergy Flow Resources


High-throughput Soaking Condition Screening for Crystalline Sponges Watch the Recording
Introducing the XtaLAB Synergy Flow for Pharmaceuticals Watch the Recording


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