TOPIQ: High-throughput Soaking Condition Screening for Crystalline Sponges

Presenter: Dr Christian Göb

This TOPIQ webinar covers the application of the XtaLAB Synergy Flow robotic sample changer to accelerate development of successful soaking conditions for crystalline sponge preparation. The crystalline sponge method requires sponges to be placed into a solution of a target analyte so that the analyte may be absorbed by the sponge, also known as soaking. Successful soaking depends on factors such as concentration and temperature. Normally, a range of conditions might be attempted and for each an X-ray diffraction experiment is performed. The XtaLAB Synergy Flow can increase throughput by allowing batches of soaked sponges to be screened automatically and unattended to determine which conditions were the most successful.