XtaLAB Synergy-ED

Fully Integrated Electron Diffractometer

A system any X-ray crystallographer will find intuitive to operate

XtaLAB Synergy-ED is a new and fully integrated electron diffractometer, creating a seamless workflow from data collection to structure determination of three-dimensional molecular structures. The key feature of this product is that it provides researchers an integrated platform enabling easy access to electron crystallography. The XtaLAB Synergy-ED is a system any X-ray crystallographer will find intuitive to operate without having to become an expert in electron microscopy.

Learn about our ED data collection service

XtaLAB Synergy-ED electron diffractometer partial cutaway) XtaLAB Synergy-ED electron diffractometer (top door open) XtaLAB Synergy-ED electron diffractometer (doors closed) XtaLAB Synergy-ED electron diffractometer (full cutaway) XtaLAB Synergy-ED detector HyPix-ED

XtaLAB Synergy-ED Overview

The XtaLAB Synergy-ED is the result of an innovative collaboration between Rigaku and JEOL, to synergistically combine our core technologies: Rigaku’s high-speed, high-sensitivity photon-counting detector (HyPix-ED) and state-of-the-art instrument control and single crystal analysis software platform (CrysAlisPro for ED), and JEOL’s long-term expertise and market leadership in designing and producing transmission electron microscopes.

Solve the unsolvable

Simply put, MicroED, also known as 3D ED, offers the chance to solve 3D structures from samples that are too small for X-ray diffraction. For X-ray crystallography, these samples would yield insufficient diffraction strength or quality to obtain a fully resolved structure. 

When you are faced with a sample that is tricky to crystallize, MicroED can let you shortcut the difficult process of optimizing the crystallization conditions. Instead, the technique allows you to obtain 3D data and structure from powders, whether you have a lot or just a little. The only requirements are that you have crystalline material and that the grains are below 1 micron in size.

It doesn’t matter if you are studying pharmaceuticals, MOFs or any other materials. If you are struggling to grow crystals, the XtaLAB Synergy-ED may help you solve your unsolvable problems.

The value of dedicated instrumentation

The XtaLAB Synergy-ED is a dedicated electron diffractometer that is operated by the same CrysAlisPro control software used to run Rigaku’s X-ray diffractometers.  Those who have used TEMs for diffraction experiments know the pain of sharing time with microscopists and/or configuring the hardware before and after use. XtaLAB Synergy-ED offers you a device specifically for diffraction so it is always calibrated and ready for diffraction and can even be installed alongside your X-ray instrumentation. CrysAlisPro controls all aspects of the diffractometer, removing the need for specialist knowledge, so even if you’ve never used an electron diffractometer before, you’ll be solving structures in no time. 

Powerful software

All of the powerful tools X-ray crystallographers have become accustomed to are available for XtaLAB Synergy-ED users as well. With CrysAlisPro-ED, you no longer need to chain together multiple pieces of software and figure out how to convert the data between each to get the job done. CrysAlisPro offers a seamless experience to get you all the way from selecting grains to measurement through to publishable data with one piece of software.

please check with your local Rigaku representative for site requirements

XtaLAB Synergy-ED Features

Fully integrated electron diffractometer creating a seamless workflow from sample screening and data collection to structure determination of three-dimensional molecular structures
Improve your ability to investigate nanocrystalline samples due to the ability of electron diffraction to measure crystals that are only a few hundred nanometers or less in size
Collect data of unrivalled quality and success rate at high throughput, without the need for complex manual alignment and configuration as required on shared general-purpose electron microscopes optimized for imaging tasks
Any X-ray crystallographer will find the XtaLAB Synergy-ED intuitive to operate, without having to become an expert in microscopy

XtaLAB Synergy-ED Videos

XtaLAB Synergy-ED Specifications

Technique 3D microcrystal electron diffraction (MicroED/3D ED) with continuous-rotation data collection
Attributes Dedicated electron diffractometer running CrysAlisPro-ED, a complete integrated software platform. Ultra-low-dose operation for sample screening and diffraction data collection. Optimized electron optics for versatile diffraction conditions without the need for regular alignment or calibration. Automation features for unattended data collection from hundreds of microcrystals
Detector High-speed, high-sensitivity hybrid pixel array detector, HyPix-ED. Variable detector distance via electron-optical projection system (10x range)
Source LaB₆ electron gun, electron energy up to 200 keV (λ = 0.0251 Å). Three-stage electron-optical condenser system
Goniometer Side-entry, single rotation axis with 160° total range
Accessories Cryo-transfer device, low-temperature, heating, gas-cell, and inert-transfer sample holders. Elemental analysis (EDS/EDX)
Computer External PC, MS Windows OS

XtaLAB Synergy-ED Options

The following accessories are available for this product:

X-ray spectrometer (JEOL JED-2300)

A fully integrated energy dispersive X-ray spectrometer providing elemental analysis on each single nanocrystal.

Cryo-transfer sample holder

Using this sample holder, a sample grid is cooled to liquid-nitrogen temperature prior to insertion, and transferred into vacuum in a protected dry environment.

High-temperature sample holder

This holder combines agile and accurate temperature control up to 1000°C with unmatched ease of use.

Gas-cell sample holder

The gas heating cell sample holder allows a specimen to be exposed to a gas environment and elevated temperatures, allowing for observation of the crystal structure during complex catalysis, adsorption, phase change, or growth processes.

XtaLAB Synergy-ED Application Notes

The following application notes are relevant to this product

XtaLAB Synergy-ED Resources

White paper

adobeSmall Crystals, Big Insights: How Electron Diffraction is Transforming Materials, Life Science, and Chemistry Research Read the White Paper

Webinars

Simple Electron Diffraction Workflow from Sample Prep to Structural Solutions Register
Solving Pharma’s Toughest Solid Form Challenges with Electron Diffraction Register
Revealing Atomic-Level Battery Material Structures with Electron Diffraction Register
Decoding the Complex Structures of MOFs for Design & Performance Insights Register
The Transformative Potential of Electron Diffraction Watch the Recording
How MicroED Is Reshaping Materials, Life Science, and Chemistry Research Watch the Recording
Illuminating the World of Sub-micron Crystal Structures with the XtaLAB Synergy-ED: A Review Watch the Recording
3D-ED in Pharmaceutical Compounds: Can we Measure Everything? Watch the Recording
XtaLAB Synergy-ED: Single Crystal Structures from Powders Watch the Recording
XtaLAB Synergy-ED Progress and Latest Results Watch the Recording
MicroED: An Update from the Rigaku/JEOL Collaboration Watch the Recording

Rigaku Journal articles

adobeStructure Analysis of Nano-Size Crystals by the XtaLAB Synergy-ED: An Integrated Platform for 3D ED/MicroED Read the Article
adobeBreaking the 1-μm barrier with the electron diffractometer XtaLAB Synergy-ED Read the Article
adobeXtaLAB Synergy-ED: An Electron Diffractometer for Routine Single Crystal Diffraction Studies Read the Article

Publications

Visit the Publication Library to access articles relevant to XtaLAB Synergy-ED

Forums

XtaLAB Synergy-ED Events

Learn more about our products at these events

  • Small Crystals, Big Insights: How Electron Diffraction is Transforming Materials, Life Science, and Chemistry Research - #3 Simple Electron Diffraction Workflow from Sample Prep to Structural Solutions
    May 6 2025 - May 6 2025
    Webinar
  • Rigaku Symposium at Yale
    May 27 2025 - May 29 2025
    New Haven, CT
  • Erice - 60th Course Electron Crystallography 2025
    May 29 2025 - June 6 2025
    Erice, Italy
  • Erice - 61st Course Quantum Crystallography 2025
    May 29 2025 - June 6 2025
    Erice, Italy
  • Small Crystals, Big Insights: How Electron Diffraction is Transforming Materials, Life Science, and Chemistry Research - #4 Solving Pharma’s Toughest Solid Form Challenges with Electron Diffraction
    June 3 2025 - June 3 2025
    Webinar
  • Polish Crystallographic Meeting 2025
    June 24 2025 - June 26 2025
    Wroclaw, Poland
  • Protein Society Meeting
    June 25 2025 - June 28 2025
    San Francisco, CA
  • Small Crystals, Big Insights: How Electron Diffraction is Transforming Materials, Life Science, and Chemistry Research - #5 Revealing Atomic-Level Battery Material Structures with Electron Diffraction
    July 8 2025 - July 8 2025
    Webinar
  • ICDM10
    July 13 2025 - July 16 2025
    Durham, UK
  • Small Crystals, Big Insights: How Electron Diffraction is Transforming Materials, Life Science, and Chemistry Research - #6 Decoding the Complex Structures of MOFs for Design & Performance Insights
    August 5 2025 - August 5 2025
    Webinar
  • ECM 35
    August 24 2025 - August 28 2025
    Poznan, Poland
  • AIC 2025 congress
    September 1 2025 - September 4 2025
    Florence Italy
  • EuroMOF 2025
    September 20 2025 - September 23 2025
    Crete, Greece
  • Rayons X et Matière 2025
    November 17 2025 - November 20 2025
    Orleans, France
  • AsCA 2025
    November 30 2025 - December 4 2025
    Taipei, Taiwan

Contact Us

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