With the use of Rigaku’s single crystal diffractometers run by CrysAlisPro/AutoChem software, crystal structures can be determined routinely in a matter of minutes. By contrast, absolute structure determination, particularly when only light atoms are present, remains a challenge. Even for some modern diffractometers long, high-redundancy measurements are necessary. In the latest generation of Rigaku’s XtaLAB Synergy systems, the combination of the latest ultrabright microfocus PhotonJet X-ray source technologies and innovative HyPix detectors allows us to lower the barrier for absolute structure determination.
This application note will showcase two examples: Naproxen, an important API molecule; and Cholestane as an example of a chiral natural product.