TOPIQ: Micro-Powder Batch Screening on a Single-Crystal Diffractometer

Single-crystal X-ray diffractometers, such as the XtaLAB Synergy series instruments, though designed for single crystal experiments, can be used to collect perfectly good powder diffraction data as well. In contrast to classical powder diffractometers, this requires only microscopic amounts of sample which further enables the use of attachments like the XtalCheck-S which is generally used for in-situ screening of crystallization plates. By combining the plate screening capability of the XtalCheck-S with powder measurements, we can utilize the single-crystal diffractometer for automatically screening large batches of samples – with up to 96 powder samples in one standard well-plate and possibly even more.