XtaLAB Synergy-R

High-Flux Rotating Anode X-ray Diffractometer

A powerful and fast system for single crystal X-ray diffraction analysis

The XtaLAB Synergy-R was designed to address the increasing need to investigate smaller and smaller samples in crystallographic research. Tightly integrating a PhotonJet-R microfocus rotating anode X-ray source with a high-speed kappa goniometer and a solid-state pixel array HPC detector creates a single crystal diffractometer that produces up to 10 times the flux as compared to a PhotonJet-S microfocus sealed tube source. The increase in flux allows you to look at much smaller crystals than before and as a side benefit it provides increased data collection speed for normal sized crystals. 

XtaLAB Synergy-R Overview

The system can be equipped with your choice of HPC hybrid photon counting detectors, the HyPix-6000HE or the curved, large theta coverage detectors, HyPix-Arc 100° or HyPix-Arc 150°. For crystallographers who wish to have a powerful, well-integrated diffractometer and only need to use one port of the rotating anode, the XtaLAB Synergy-R provides the perfect combination of high-flux performance with a low-noise HPC X-ray detector.


The PhotonJet-R comes from the same pedigree as the MicroMax™-007 HF, of which there are well over 1000 units in use around the world. The PhotonJet-R X-ray source applies the lessons learned over the development and lifetime of the MicroMax-007 rotating anode to produce a new generation, high performance rotating anode source. With the source mounted directly onto the goniometer the XtaLAB Synergy-R provides a stable and robust solution which ensures consistently high performance. Confocal optics, designed by Rigaku Innovative Technologies, offer a high-brilliance X-ray beam and the optional continuously variable slit assembly gives the user the ability to adjust high brilliance versus low divergence depending on the needs of the sample being studied.

Proven reliability

The PhotonJet-R source was designed with reliability in mind. Clever Rigaku engineering makes filament changes easy, like swapping a printer cartridge, with no need to realign the source each time. Scheduled maintenance involves one annual visit from a Rigaku engineer, as with all XtaLAB Synergy diffractometers, and typically takes 1-2 days. With the anode exchange program, you get the benefit of rotating anode power with the convenience of sealed tubes.

Beam conditioning

Where overlapping peaks are a concern, e.g. large unit cells, twins or incommensurate lattices, high beam divergence is undesirable. On the PhotonJet-R source, a software controlled, motorized variable beam slit is available as an option to alter divergence to adapt the source to your sample’s requirements. For those samples where intensity matters most, the slit can be fully opened giving the highest flux. For those where peak sharpness and overlap are factors, the beam can be limited to a divergence anywhere between 1 to 10 mrad.

HyPix detectors

Rigaku’s own HyPix family of HPC detectors use solid state pixel array technology to enable direct X-ray photon detection and counting. Direct X-ray photon detection means that X-ray photons are counted instantaneously as they arrive at the detector. There is no conversion to visible light by a scintillator so the energy of the photon can be assessed at moment of detection. This leads to essentially noise free images. The HyPix detectors feature a 100 Hz frame rate which allows for data fine slicing even at the fastest goniometer speeds. The HyPix detectors incorporate dual counters enabling several modes of operation. Rapid alternating counter electronics (RACE) technology enables the 100 Hz zero dead time mode, ensures that no pixel is blind for more than a few nanoseconds during exposure to X-rays. The high dynamic range mode combines the counters to offer a massive 31-bit counter depth. Dual thresholding offers differential modes and selective signal suppression.


The XtaLAB Synergy-R comes complete with CrysAlisPro, our user-inspired data collection and data processing software for single crystal analysis. Designed around an easy-to-use graphical user interface, CrysAlisPro can be operated under fully automatic, semi-automatic or manual control. CrysAlisPro combines automated crystal screening, the fastest and most accurate strategy software available, concurrent data reduction and automatic small molecule structure solution. CrysAlisPro can operate either in a protein or small molecule dedicated workflow. Popular third-party protein data processing packages can easily process diffraction data if desired. Visual feedback is provided for each step with clear, color-coded guidance so that both novices and experts can collect high-quality data in the shortest time possible.


AutoChem is the ultimate productivity tool for small molecule chemists, offering fast, fully automatic structure solution and refinement during data collection. Developed in collaboration with OlexSys Ltd (Durham University, UK), AutoChem works in conjunction with Olex² where more advanced structure solution and refinement functionality exists. AutoChem is seamlessly integrated within CrysAlisPro, and forms an integral part of our ‘What is this?’ feature. The ‘What is this?’ feature gives you structures quickly and ensures you are not wasting time collecting full datasets on known samples or starting materials. It is an alternative pre-experiment option, which is used to plan your full data collections.

XtaLAB Synergy-R Features

Faster, accurate data collection
due to high-speed kappa goniometer, high-flux rotating anode X-ray source, fast, low-noise X-ray detector, and highly optimized instrument control software
Improve your ability to investigate small samples
due to the increased flux from the rotating anode X-ray source as well as the extreme low noise of the HyPix X-ray detectors. Noise free images mean you can count longer for weakly diffracting crystals without a loss in data quality arising from detector noise
Highest level of user safety
with multiply redundant electromechanical safety circuits built into the ergonomically designed radiation enclosure
Minimize your downtime
by utilizing built-in online diagnostics and troubleshooting to diagnose and fix almost all problems without a site visit
Automatically solve structures
and determine what your sample is in a few seconds before committing to a full dataset by using the “What is this?” feature
Increased data collection speed
due to the increased flux of the X-ray source
Enhance your ability to resolve large unit cells, twins or incommensurate lattices
when you select the optional motorized variable beam slit in order to alter divergence to adapt the source to your sample’s requirements

XtaLAB Synergy-R Specifications

Technique Single crystal X-ray diffraction
Attributes Microfocus rotating anode X-ray source diffractometer with hybrid pixel array detector and kappa goniometer
Detectors HyPix-6000HE or optionally the large theta coverage detectors HyPix-Arc 100° or HyPix-Arc 150°
X-ray Source PhotonJet-R X-ray source with MicroMax-007 rotating anode, which incorporates a new mirror design and new alignment hardware. Two target types are available (Mo or Cu)
Goniometer Fast kappa geometry goniometer, which allows data collection scan speeds of up to 10°/sec
Accessories Oxford Cryostream 1000, Oxford Cobra, XtaLAB Flow robotic system, XtalCheck-S, High Pressure Kit
Computer External PC, MS Windows OS
Dimensions 1300 (W) x 1875 (H) x 850 (D) (mm)
Mass 600 kg (core unit)
Power requirements 1Ø, 200-230 V, 20 A

XtaLAB Synergy-R Options

XtaLAB Synergy-R Application Notes

The following application notes are relevant to this product

XtaLAB Synergy-R Resources


Pump-Multiprobe Photocrystallography on the XtaLAB Synergy-R System Watch the Recording
High-throughput Soaking Condition Screening for Crystalline Sponges Watch the Recording
Micro-Powder Batch Screening on a Single-Crystal Diffractometer Watch the Recording
Diffraction Methods for MOF Investigations Watch the Recording

Rigaku Journal articles

adobeDiffractometers for modern X-ray crystallography: The XtaLAB Synergy X-ray diffractometer platform Read the Article
adobeX-ray diffractometer system with single or dual PhotonJet microfocus sources Read the Article
adobeSingle crystal diffraction systems based on hybrid pixel array technology Read the Article


Visit the Publication Library to access articles relevant to XtaLAB Synergy-R


XtaLAB Synergy-R Events

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  • This new machine with a rotating anode generator has been a game changer for our institute. Data from good-diffracting crystals can be collected within minutes!
    Read more
    Dr. Krzysztof Radacki
    University of Wuerzburg
  • The Synergy-R is a fantastic machine and we would unconditionally recommend scheduling a demo, if your institution would like to amplify their lab's capabilities with a high-end diffractometer.
    Read more
    Dr. Michael Wörle, Head and Dr. Nils Trapp, Senior Scientist
    Small Molecule Crystallography Center, ETH Zürich

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