XtaLAB SynergyCustom
Customized Single Crystal Diffraction System with Microfocus Rotating Anode Generator
X-ray crystal structure determination and SAXS for macromolecules
One of the advantages of Rigaku's rotating anode X-ray generators is the ability to utilize both ports of the generator simultaneously. This might involve having two single crystal goniometers mounted on the generator or it might involve having one goniometer with a sample changing robot on one port dedicated to protein crystallography and a second goniometer dedicated to chemical crystallography.
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XtaLAB SynergyCustom Overview
XtaLAB SynergyCustom
One of the advantages of Rigaku's rotating anode X-ray generators is the ability to utilize both ports of the generator simultaneously. This might involve having two single crystal goniometers mounted on the generator or it might involve having one goniometer with a sample changing robot on one port dedicated to protein crystallography and a second goniometer dedicated to chemical crystallography. In order to accommodate the various configurations that a researcher might envision, Rigaku offers the XtaLAB SynergyCustom, a system that can be configured with either a MicroMax-007 HF microfocus rotating anode source or the highest-flux in-house X-ray source, the FR-X. Additionally, the XtaLAB SynergyCustom comes in a specially designed enclosure with your choice of table size to accommodate accessory equipment, such as an ACTOR 2 robotic system or a microscope close to the goniometer. Thus, the versatility offered by the XtaLAB SynergyCustom system provides the most flexibility possible for your structural chemistry program.
HPC direct detection X-ray detector
XtaLAB SynergyCustom systems are configured with a Hybrid Photon Counting (HPC) X-ray detector, such as the HyPix-6000HE, the HyPix-Arc 150° or HyPix-Arc 100°. HPC detectors are ideal for difficult single crystal experiments because they are photon counting detectors that directly detect X-ray photons without the need for the intermediate step of converting X-ray photons to light with a phosphor or scintillator. As a result, HPCs have high dynamic range, fast readout speed and extremely low noise. Additionally, HPC X-ray detectors have a top-hat point spread function of a single pixel. These combined features, along with shutterless data collection, mean that you can collect more accurate diffraction data, faster. As a result, the XtaLAB SynergyCustom systems offer outstanding performance for demanding single crystal X-ray diffraction experiments.
CrysAlisPro
The XtaLAB SynergyCustom comes complete with CrysAlisPro, our user-inspired data collection and data processing software for single crystal analysis. Designed around an easy-to-use graphical user interface, CrysAlisPro can be operated under fully automatic, semi-automatic or manual control. CrysAlisPro combines automated crystal screening, the fastest and most accurate strategy software available, concurrent data reduction and automatic small molecule structure solution. Visual feedback is provided for each step with clear, color-coded guidance so that both novices and experts can collect high-quality data in the shortest time possible. CrysAlisPro can operate either in a protein or small molecule dedicated workflow. Popular third-party protein data processing packages can easily process diffraction data if desired.
AutoChem
AutoChem is the ultimate productivity tool for small molecule chemists, offering fast, fully automatic structure solution and refinement during data collection. Developed in collaboration with OlexSys Ltd (Durham University, UK), AutoChem works in conjunction with Olex² where more advanced structure solution and refinement functionality exists. AutoChem is seamlessly integrated within CrysAlisPro, and forms an integral part of our ‘What is this?’ feature. The ‘What is this?’ feature gives you structures quickly and ensures you are not wasting time collecting full datasets on known samples or starting materials. It is an alternative pre-experiment option, which is used to plan your full data collections.
XtaLAB SynergyCustom Features
XtaLAB SynergyCustom Specifications
| Attributes | X-ray diffractometer with dual port rotating anode X-ray source and HPC detector | |
|---|---|---|
| Detectors | HyPix-6000HE or optionally the large theta coverage detectors HyPix-Arc 100° or HyPix-Arc 150° or the DECTRIS EIGER 4M | |
| X-ray source | MicroMax-007 HF microfocus rotating anode source or the highest-flux in-house X-ray source, the FR-X (Mo, Cu, or Cr). | |
| Goniometer | Fast kappa geometry goniometer that allows data collection scan speeds of up to 10°/sec | |
| Accessories | Oxford Cryostream 1000, Oxford Cobra, XtalCheck-S, High Pressure Kit, ACTOR 2 robotic sample changer | |
| Computer | External PC, MS Windows OS | |
XtaLAB SynergyCustom Options
The following accessories are available for this product:
ACTOR 2
The ACTOR 2 eliminates much of the physical handling of samples required during crystal screening and data collection
High Pressure Kit
Accommodating the vast majority of commercially available and custom high pressure cells, the high pressure kit creates a sample space with an 8 cm diameter.
HyPix-Arc 100°
A curved single crystal X-ray diffraction detector based on direct X-ray detection technology with a higher 2θ range compared to a flat detector.
HyPix-Arc 150°
An optional, unique curved Hybrid Photon Counting (HPC) X-ray detector for single crystal diffraction applications.
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Intelligent Goniometer Head 2 (IGH2)
The smallest detachable motorized goniometer head on the market.
Intelligent Optics Module (iOM)
A fully automatic optic alignment system. Achieve peak source performance any time with Intelligent Optics Module (iOM) automated alignment. To learn more, visit the product page.
Oxford Cobra
Offers the ultimate solution for both macromolecular and small molecule crystallography.
XtalCheck-S
With this system, one can easily survey many crystallization experiments by eliminating the need to harvest and cryo-cool samples.
XtaLAB SynergyCustom Application Notes
The following application notes are relevant to this product
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PX030 - Using CrysAlisᴾʳᵒ to tackle macromolecular non-merohedral twins
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PHRM0001 - Crystalline Sponge Method on XtaLAB Synergy Systems
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B-SCX1011 - High-Speed Measurement Of A Peptide Drug Using HyPix-Arc 150°
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SMX034 - The Molecular Grabber Method: Another Crystalline Sponge using Protein
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PX015 - Data Collection and Improved Spot Resolution with the HyPix-6000HE HPC Detector
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SMX038 - Rigaku Rotating Anodes: Powerful and Reliable Sources for Seamless and High-throughput Small Molecule Structure Solution
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PX028 - Resolving Large Unit Cells by using the Correct Detector, Distance, and Beam Divergence
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PX024 - Lysozyme S-SAD Phasing with Two Minutes of Data Collection on the XtaLAB SynergyCustom
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SMX024 - Charge-density Data Collection on XtaLAB Synergy Diffractometers
XtaLAB SynergyCustom Resources
Webinars
| What To Do When the Lights Go Out - Rethinking the Homelab for Structural Biology Research | Watch the Recording |
| Processing a PX data set with CrysAlisᴾʳᵒ | Watch the Recording |
Rigaku Journal articles
 The “Molecular Grabber” method: Development of new crystalline sponge method New Idea for structural analysis of compounds using protein |
Read the Article |
| Single crystal diffraction systems based on hybrid pixel array technology |
Read the Article |
Publications
Visit the Publication Library to access articles relevant to XtaLAB SynergyCustom
Forums
XtaLAB SynergyCustom Events
Learn more about our products at these events
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EventDatesLocationEvent website
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ISMSC 2025May 24 2025 - May 29 2025Kyoto, Japan
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Rigaku Symposium at YaleMay 27 2025 - May 28 2025New Haven, CT
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Erice - 60th Course Electron Crystallography 2025May 29 2025 - June 6 2025Erice, Italy
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Erice - 61st Course Quantum Crystallography 2025May 29 2025 - June 6 2025Erice, Italy
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Polish Crystallographic Meeting 2025June 24 2025 - June 26 2025Wroclaw, Poland
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Protein Society MeetingJune 25 2025 - June 28 2025San Francisco, CA
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ICDM10July 13 2025 - July 16 2025Durham, UK
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ECM 35August 24 2025 - August 28 2025Poznan, Poland
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AIC 2025 congressSeptember 1 2025 - September 4 2025Florence Italy
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EuroMOF 2025September 20 2025 - September 23 2025Crete, Greece
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ROD Single Crystal User MeetingOctober 6 2025 - October 7 2025Neu Isenburg, Germany
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Rayons X et Matière 2025November 17 2025 - November 20 2025Orleans, France
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AsCA 2025November 30 2025 - December 4 2025Taipei, Taiwan
Contact Us
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