Insight Chips Liquid Nano-Channel Sample Holder

The Liquid Nano-Channel Sample Holder, developed by Insight Chips and fully supported on the XtaLAB Synergy-ED, enables electron diffraction experiments in liquid environments with unmatched simplicity and precision. This technology allows researchers to study samples exposed to liquid environments, grow crystals directly from solution inside the nano-channels and study crystal growth kinetics.

Key features

• Native-state measurements – Preserve structural integrity by studying samples directly in liquid at room temperature.
• In-channel crystal growth – Grow and analyze crystals in situ within nano-channels.
• Streamlined workflow – Easy chip preparation, wide tilt range and large field of view for smooth integration with Synergy-ED experiments.
• Dynamic process observation – Monitor nucleation, polymorph transitions, and crystal growth kinetics in real time.
• Optional four-channel controlled flow system for dynamic mixing and solvent exchange experiments

Applications

• Pharmaceutical research – Identify early and transient polymorphs important for drug development.
• Metal–organic frameworks (MOFs) – Observe crystal growth mechanisms and kinetics live inside the microscope as well as studying the absorptions of different solvents into MOF pores.
• Materials science – Extend liquid-phase diffraction studies across catalysis, energy, and advanced functional materials.