Pharmalytical Summit 2021
Drug Formulation

X-ray powder diffractometer (XRPD) and X-ray single crystal diffractometer are known and used in pharmaceutical research, formulation, and manufacturing. However, it is not well-known a modern laboratory XRD has more advanced options, which provide unique information compared to XRPD. In this presentation, differential scanning calorimetry (DSC) combined with XRPD and Ka1 Johansson configuration for indexing application will be discussed.

Despite being an X-ray diffractometer designed for single crystal crystallography, the XtaLAB Synergy-S is also a great tool for the measurement of powder samples. The following features are of particular interest to the pharmaceutical industry:

• Data collection on tiny amounts of sample.
• Use of Gandolfi strategies for data collection, so data is collected with several orientations of the powder holder in the beam.
• Better statistics on weak data, via the direct photon counting technology used by the Rigaku HyPix detectors.
• Improved peak resolution, thanks to the single-pixel point-spread-function of the HyPix detectors and a computer-controller beam divergence slit.
• Batch screening of up to 96 powder samples without user intervention in between samples, using an in-situ plate screener directly mounted on the goniometer.

In this presentation, explanations will be given about how the above-mentioned features are achieved and some data will be presented.