Pharmalytical Summit 2021
Drug Discovery

We will discuss the use of Rigaku’s exclusive PharmPAK application package to prescreen 18 elements commonly used as synthetic catalysts. This technique can be used for analytical support for development and process chemistry. This XRF analysis uses ~50mg of retrievable sample as a pre-screen for ICP for elemental impurities and catalyst residues.

The XtaLAB Synergy Flow turns any Synergy cabinet diffractometer into an automated, high-throughput machine by incorporating a 6-axis UR3 Universal Robot and a 3-puck dewar. The Flow system can automatically screen and collect 48 crystal samples with minimal human intervention. CrysAlisPro has been upgraded with tools to control all aspects of robotics and sample queuing. A unique X-ray safe dewar-drawer system allows loading and unloading of pucks without opening the X-ray enclosure or disturbing data collection. Ultimately, the XtaLAB Synergy Flow system is the perfect solution to allow full-time use of your diffractometer during a time when human interaction and contamination must be minimized.

Small angle X-ray scattering (SAXS) provides information on particle size and shape, as well as particle packing. Moreover, this technique is suitable to study a range of samples from very dilute to highly concentrated. A number of pharmaceutical delivery technologies have strict particle size limitations. X-ray small angle scattering can be a powerful technique giving critical information on particle size down to small lengths scales. This presentation will describe the basics of SAXS as well as some applications applied to pharmaceutically relevant samples.

On synthesis of a new molecular entity, one of the first tasks is to confirm the molecular structure. While molecular structure determination utilizing X-ray diffraction has become routine for ordered crystalline materials, there has been no similar diffraction solution for amorphous materials. Learn about recent breakthroughs in molecular structure determination utilizing atomic pair distribution function analysis for non-crystalline materials.