Application Note PHARM012
Introduction
In the initial stage of studying crystallization conditions for pharmaceuticals, there are many cases where only very small amounts of crystals (several hundred μg to less than 1 mg) can be obtained. Here, we introduce an example of measurement using a desktop XRD system combined with a zero - background sample holder.
Crystalline phase analysis
| Analysis: | Tablet fine powder |
| Use: | Formulation (Dosage Form) |
| Analyzed materials: | Theodol tablet |
| Analysis software: | SmartLab Studio II |
Figure 1: X-ray diffraction profile and qualitative analysis results of 0.05 mg theodol tablets.
Conclusion
Figure 1 is a diffraction profile of 0.05 mg powder of theodol tablet placed on a zero - background sample holder and measured using desktop XRD for about 1 minute. Clear peaks were obtained even from such a small amount of sample, and the intensity was sufficient for qualitative analysis. In the measurement, lactose was identified in addition to theophylline anhydride. By utilizing the zero - background sample holder, highly sensitive detection in a short time is possible even for trace samples in the initial stages of development.
