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Chemical / small molecule crystallography

Chemical / small molecule crystallography

Determine the three dimensional structure of molecules

IUCr Corporate associateSometimes referred to as small molecule crystallography, this technique employs single crystal X-ray diffraction (SXRD) to unambiguously determine the three dimensional structure of molecules. The technique involves the use of crystallography to study problems which are primarily of a chemical nature and provides accurate and precise measurements of molecular dimensions in a way that no other method can approach. Chemical crystallography may be applied to compounds of both chemical and biological interest, including: new synthetic chemicals, catalysts, pharmaceuticals, and natural products. A frequent use is the identification of natural products, or of the products of synthetic chemistry experiments; however, detailed molecular geometry, intermolecular interactions and absolute configuration can also be studied.

  • Crystal structure determination
  • Molecular structure and geometry
  • Absolute structure and configuration
  • Single crystal diffraction
  • Powder diffraction,
    • Ambient and non-ambient conditions
    • Displacement parameters
    • Charge density
    • Intermolecular interactions
    • Structure correlation

    Rigaku recommends the following systems:

    A benchtop single crystal X-ray diffractometer with the latest technology HPC X-ray detector, ideal for self-service crystallography.

    Automated tool for performing in situ crystallography experiments on existing X-ray diffractometers

    A microfocus single crystal X-ray diffractometer configured with an HPC direct detection X-ray detector and either one or two microfocus X-ray sources.

    A high performance single crystal rotating anode X-ray diffractometer with a low noise direct detection HPC X-ray detector.

    A high-flux, versatile X-ray diffractometer with HPC X-ray detector for multipurpose diffraction experiments and small samples

    An upgradeable single crystal X-ray diffractometer for structural analysis of small molecule samples

    A bespoke single crystal X-ray diffractometer with custom enclosure and the flexibility to utilize both ports of a rotating anode X-ray source.

    User-inspired data collection and data processing software for small molecule and protein crystallography

    A unique curved single crystal X-ray diffraction detector

    Low noise, sensitive, air-cooled X-ray detector for superior X-ray diffraction data quality

    Compact, highly sensitive X-ray detector for single crystal applications

    Automated crystal transport, orientation and retrieval robot